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[1] Mills A, Crofoot G Jr, McDonald C, Shalit P, Flamm JA, Gathe J Jr, Scribner A, Shamblaw D, Saag M, Cao H, Martin H, Das M, Thomas A, Liu HC, Yan M, Callebaut C, Custodio J, Cheng A, McCallister S. Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate in the First Protease Inhibitor-Based Single-Tablet Regimen for Initial HIV-1 Therapy: A Randomized Phase 2 Study. J Acquir Immune Defic Syndr. 2015 Aug 1;69(4):439-45. doi: 10.1097/QAI.0000000000000618. PMID: 25867913.
[2] Ray AS, Fordyce MW, Hitchcock MJ. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus. Antiviral Res. 2016 Jan;125:63-70. doi: 10.1016/j.antiviral.2015.11.009. Epub 2015 Nov 27. PMID: 26640223.
[3] Li X, Tan XY, Cui XJ, Yang M, Chen C, Chen XY. Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations. Pharmgenomics Pers Med. 2021 Oct 14;14:1315-1329. doi: 10.2147/PGPM.S329690. PMID: 34703277; PMCID: PMC8525415.
[4] ÎâСÑÞ,ÓÚºÆ,ÖÜÑó,µÈ. ¸»ÂíËá±û·ÓÌæÅµ¸£Î¤Ó븻ÂíËáÌæÅµ¸£Î¤¶þßÁß»õ¥¶ÔѪ֬ӰÏìµÄmetaÆÊÎö[J]. Ò©Îï²»Á¼·´Ó¦ÔÓÖ¾,2021,23(11):584-591. DOI:10.3760/cma.j.cn114015-20211013-01064.
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